There is increased awareness that the mental, emotional, and spiritual components of a patient’s life are major determinants of the quality of life, health outcomes, and economic outcomes for that individual and their family. Unfortunately, many people have been taught by their medical team or others in their life that there is nothing they can do about the challenges they face. However, there are many individuals with “grit” who have achieved the impossible, overcoming critical hardships, severe health challenges, or disability. It is possible to improve one’s grit and have much greater resilience in the face of major health or other life challenges.